Young graduate Lisa Bentini gets her first substitute teaching job in a middle school in Bologna. In Naples, teacher Silvana De Fazio prepares her last class for her high school graduation before retiring. Professor Dario Tulipano, a precarious worker from Palermo, moves to Bolzano for an annual substitution. Born out of the director's own teaching experience, Signori professori interweaves three different experiences to recount the world of school from the side of the professors, between expectations and fulfilment, vocation and frustration, passion and bewilderment.

Maura Delpero (Bolzano, 1975) studied literature in Bologna and Paris-Sorbonne, specialising in dramaturgy in Buenos Aires. She made her debut in documentaries with Moglie e buoi dei paesi tuoi (2005), Maternal (2019), his first fiction film, was in Locarno, while the following Vermiglio (2024) was awarded in Venice.